Drug delivery to the posterior segment of the eye for pharmacologic therapy
نویسندگان
چکیده
منابع مشابه
review of intravitreal implants for extended drug delivery to the posterior segment of the eye
intravitreal injection is the most common approach for drug delivery to the posterior segment in humans. however, following the injection, drugs are rapidly eliminated from the vitreous, with half-lives up to a few days. depending on the rate of clearance from the vitreous, large boluses and frequent administrations may be required to ensure therapeutic levels over an extended period of time. m...
متن کاملDrug delivery for posterior segment eye disease.
In recent years, significant advances have been made in optimizing the delivery of drugs to target tissues within the eye and in maintaining effective drug doses within those tissues. Most pharmacologic management of ocular disease, however, continues to use the topical application of solutions to the surface of the eye as drops. Factors that can limit the usefulness of topical drug application...
متن کاملThermoresponsive hydrogels as a new ocular drug delivery platform to the posterior segment of the eye.
PURPOSE To characterize thermoresponsive hydrogels (liquids at room temperature, gels at body temperature) as a novel drug delivery platform to the posterior segment. METHODS Thermoresponsive hydrogels were synthesized using poly(N-isopropylacrylamide) (PNIPAAm), cross-linked with poly(ethylene glycol) diacrylate (PEG-DA). Proteins were then encapsulated into the hydrogels, including bovine s...
متن کاملOcular Drug Delivery: Targeting the Posterior Segment
An inch or less. That is the short distance an ocular drug must travel to reach a target site at the back of the eye. Research has traveled a long way over the past 4 decades in efforts to make this inch-long journey more successful. Delivering ocular drugs to their target tissues often requires them to traverse the fatwater-fat structure of the corneal barrier, while ensuring minimum wastage t...
متن کاملOcular Drug Delivery: Targeting the Posterior Segment
One inch or less. That is the short distance an ocular drug must travel to reach a target site at the back of the eye. Research has come a long way over the past 4 decades in efforts to make this inch-long journey more successful. Delivering ocular drugs to their target tissues often requires them to traverse the fat-water-fat structure of the corneal barrier while ensuring minimum wastage thro...
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ژورنال
عنوان ژورنال: Expert Review of Ophthalmology
سال: 2010
ISSN: 1746-9899,1746-9902
DOI: 10.1586/eop.09.70